Tuesday, November 13, 2018

LIMS for Specialty Diagnostic Labs

SPECIALTY DIAGNOSTICS WORLD
Modern specialty diagnostic laboratories need an integrated LIMS that can handle molecular diagnostics, cytology, histopathology, NGS, FLOW, bio-chemistry, genetic cytology (Cyto/ FISH) and microbiology related processes in a single system. Advanced detection of mutations, abnormalities in cells, chromosomes, karyotypes, DNA, gene, enzymes studies and biomarkers are very helpful in identification of potential source of disease and better patient care.

 FUNCTIONAL ASPECTS OF AUTOMATING SUCH LABS
Specialty diagnostic labs need a system that can handle multiple workflow processes in a seamless & communicative manner. In order to publish a result, samples undergo several pre-processing like aliquoting, isolation, normalization, robotic pipetting, reagent addition including sample preparation and analysis on high throughput devices that are capable of handling different plates & containers for more info visit lims software provider. The ultimate goal is to reach the level of getting to the final outcome of a test. From a data entry and result publishing perspective, it may look pretty simple which even a traditional LIMS is quite good at handling. However, dynamic workflows with dynamic content capture is one of the key aspects.

PATIENT DEMOGRAPHY
Most demographic information comes in as paper-based or electronic data exchange can happen between LIMS and external hospital or clinical systems. Middleware system for Electronic Data Interchange (EDI) should be available for bi-directional communication of patient demography, orders and results with healthcare systems. Patient demography could also include hereditary information for advanced research studies based on pedigree.


LIMS software solutions

SAMPLE ACCESSIONING / REGISTRATION & BIOBANK STORAGE
Sample accessioning/ registration with patient demographics and appropriate routing of source sample for processing and storage is a critical step for any molecular laboratory. More often the DNA/RNA needs to be isolated within a specific time frame after the phlebotomy. QC for LIMS. Routing of samples to the appropriate workflow process becomes important when it comes to following the SOPs and throughput of the lab. Biobank storage involves temporary refrigerators, deep freezers and cryo-storage equipment. Biobank storage should be really flexible in terms of the definition of templates for various types of storage locations and destination containers (plates, tube-holders). Movement between the biobank and the processing area is an important process which goes through requesting and issuing samples based on priority and the process it needs to undergo.


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